Publications

Current Trainees Publication Summary

Mirlekar B, Michaud D, Pylayeva-Gupta Y. IL-35 Detection in B Cells at the mRNA and Protein Level. Methods Mol Biol. 2021;2270:125-147. doi: 10.1007/978-1-0716-1237-8_8. PMID: 33479897.

Alcedo KP, Rouse MA, Jung GS, Fu D, Minor M, Willcockson HH, Greene KG, Snider NT. CD73 maintains hepatocyte metabolic integrity and mouse liver homeostasis in a sex-dependent manner. Cell Mol Gastroenterol Hepatol. 2021 Jan 28:S2352-345X(21)00022-9. doi: 10.1016/j.jcmgh.2021.01.016. Epub ahead of print. PMID: 33516905.

Michaud D, Steward CR, Mirlekar B, Playeva-Gupta Y. Regulatory B cells in cancer. Immunol Rev. 2020 Dec 23. doi: 10.1111/imr.12939. Epub ahead of print. PMID: 33368346.

Franks JL, Martinez-Chacin RC, Wang X, Tiedemann RL, Bonacci T, Choudhury R, Bolhuis DL, Enrico TP, Mouery RD, Damrauer JS, Yan F, Harrison JS, Major MB, Hoadley KA, Suzuki A, Rothbart SB, Brown NG, Emanuele MJ. In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators. PLoS Biol. 2020 Dec 11;18(12):e3000975. doi: 10.1371/journal.pbio.3000975. PMID: 33306668; PMCID: PMC7758050.

Veleta KA, Cleveland AH, Babcock BR, He YW, Hwang D, Sokolsky-Papkov M, Gershon TR. Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. Cell Death Differ. 2020 Dec 8. doi: 10.1038/s41418-020-00687-7. Epub ahead of print. PMID: 33293647.

Leon E, Ranganathan R, Savoldo B. Adoptive T cell therapy: Boosting the immune system to fight cancer. Semin Immunol. 2020 Jun;49:101437. doi: 10.1016/j.smim.2020.101437. Epub 2020 Nov 29. PMID: 33262066; PMCID: PMC7738356.

Mouery BL, Mei L, Cook JG. Programming pluripotent stem cells: Can’t teach an old cell new DNA replication tricks. J Cell Biol. 2020 Sep 7;219(9):e202008014. doi: 10.1083/jcb.202008014. PMID: 32858750; PMCID: PMC7480109.

Kwon HB, Mackie DI, Bonnavion R, Mercier AL, Helker CSM, Son T, Guenter S, Serafin DS, Kim KW, Offermanns S, Caron KM, Stainier DYR. The Orphan G-Protein Coupled Receptor 182 Is a Negative Regulator of Definitive Hematopoiesis through Leukotriene B4 Signaling. ACS Pharmacol Transl Sci. 2020 Jun 24;3(4):676-689. doi: 10.1021/acsptsci.0c00020. PMID: 32832870; PMCID: PMC7432686.

Ozkan-Dagliyan I, Diehl JN, George SD, Schaefer A, Papke B, Klotz-Noack K, Waters AM, Goodwin CM, Gautam P, Pierobon M, Peng S, Gilbert TSK, Lin KH, Dagliyan O, Wennerberg K, Petricoin EF 3rd, Tran NL, Bhagwat SV, Tiu RV, Peng SB, Herring LE, Graves LM, Sers C, Wood KC, Cox AD, Der CJ. Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers. Cell Rep. 2020 Jun 16;31(11):107764. doi: 10.1016/j.celrep.2020.107764. PMID: 32553168; PMCID: PMC7393480.

Emanuele MJ, Enrico TP, Mouery RD, Wasserman D, Nachum S, Tzur A. Complex Cartography: Regulation of E2F Transcription Factors by Cyclin F and Ubiquitin. Trends Cell Biol. 2020 Aug;30(8):640-652. doi: 10.1016/j.tcb.2020.05.002. Epub 2020 Jun 5. PMID: 32513610.

Kren N, Michaud D, Bagchi S, Greene K, Pylayeva-Gupta Y. Rab27a plays a dual role in metastatic propensity of pancreatic cancer. Sci Rep. 2020 Apr 30;10(1):7390. doi: 10.1038/s41598-020-64248-1. PMID: 32355248; PMCID: PMC7193593.

Lee SE, Alcedo KP*, Kim HJ, Snider NT. Alternative Splicing in Hepatocellular Carcinoma. Cell Mol Gastroenterol Hepatol. 2020;10(4):699-712. doi: 10.1016/j.jcmgh.2020.04.018. Epub 2020 May 8. PMID: 32389640; PMCID: PMC7490524.

Meriesh HA, Lerner AM, Chandrasekharan MB, Strahl BD. The histone H4 basic patch regulates SAGA-mediated H2B deubiquitination and histone acetylation. J Biol Chem. 2020 May 8;295(19):6561-6569. doi: 10.1074/jbc.RA120.013196. Epub 2020 Apr 3. PMID: 32245891; PMCID: PMC7212633.

Serafin DS, Harris NR, Nielsen NR, Mackie DI, Caron KM. Dawn of a New RAMPage. Trends Pharmacol Sci. 2020 Apr;41(4):249-265. doi: 10.1016/j.tips.2020.01.009. Epub 2020 Feb 27. PMID: 32115276; PMCID: PMC7236817.

Ma X, Shou P, Smith C, Chen Y, Du H, Sun C, Porterfield Kren N, Michaud D, Ahn S, Vincent B, Savoldo B, Pylayeva-Gupta Y, Zhang S, Dotti G, Xu Y. Interleukin-23 engineering improves CAR T cell function in solid tumors. Nat Biotechnol. 2020 Apr;38(4):448-459. doi: 10.1038/s41587-019-0398-2. Epub 2020 Feb 3. PMID: 32015548; PMCID: PMC7466194.

Mirlekar B, Michaud D, Lee SJ, Kren NP, Harris C, Greene K, Goldman EC, Gupta GP, Fields RC, Hawkins WG, DeNardo DG, Rashid NU, Yeh JJ, McRee AJ, Vincent BG, Vignali DAA, Pylayeva-Gupta Y. B cell-Derived IL35 Drives STAT3-Dependent CD8⁺ T-cell Exclusion in Pancreatic Cancer. Cancer Immunol Res. 2020 Mar;8(3):292-308. doi: 10.1158/2326-6066.CIR-19-0349. Epub 2020 Feb 5. PMID: 32024640; PMCID: PMC7056532.

Fagan-Solis KD, Simpson DA, Kumar RJ, Martelotto LG, Mose LE, Rashid NU, Ho AY, Powell SN, Wen YH, Parker JS, Reis-Filho JS, Petrini JHJ, Gupta GP. A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Rep. 2020 Feb 4;30(5):1385-1399.e7. doi: 10.1016/j.celrep.2020.01.020. PMID: 32023457; PMCID: PMC7361372.

Zhang H, Schaefer A, Wang Y, Hodge RG, Blake DR, Diehl JN, Papageorge AG, Stachler MD, Liao J, Zhou J, Wu Z, Akarca FG, de Klerk LK, Derks S, Pierobon M, Hoadley KA, Wang TC, Church G, Wong KK, Petricoin EF, Cox AD, Lowy DR, Der CJ, Bass AJ. Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer. Cancer Discov. 2020 Feb;10(2):288-305. doi: 10.1158/2159-8290.CD-19-0811. Epub 2019 Nov 26. PMID: 31771969; PMCID: PMC7007383.

Michaud D, Mirlekar B, Bischoff S, Cowley DO, Vignali DAA, Pylayeva-Gupta Y. Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3. Cytokine. 2020 Jan;125:154817. doi: 10.1016/j.cyto.2019.154817. Epub 2019 Aug 28. PMID: 31472403; PMCID: PMC6876557.

Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Atypical KRAS^G12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer. Cancer Discov. 2020 Jan;10(1):104-123. doi: 10.1158/2159-8290.CD-19-1006. Epub 2019 Oct 24. PMID: 31649109; PMCID: PMC6954322.

Minor M, Alcedo KP, Battaglia RA, Snider NT. Cell type- and tissue-specific functions of ecto-5′-nucleotidase (CD73). Am J Physiol Cell Physiol. 2019 Dec 1;317(6):C1079-C1092. doi: 10.1152/ajpcell.00285.2019. Epub 2019 Aug 28. PMID: 31461341; PMCID: PMC6957383.

Hollern DP, Xu N, Thennavan A, Glodowski C, Garcia-Recio S, Mott KR, He X, Garay JP, Carey-Ewend K, Marron D, Ford J, Liu S, Vick SC, Martin M, Parker JS, Vincent BG, Serody JS, Perou CM. B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer. Cell. 2019 Nov 14;179(5):1191-1206.e21. doi: 10.1016/j.cell.2019.10.028. PMID: 31730857; PMCID: PMC6911685.

Alcedo KP, Guerrero A, Basrur V, Fu D, Richardson ML, McLane JS, Tsou CC, Nesvizhskii AI, Welling TH, Lebrilla CB, Otey CA, Kim HJ, Omary MB, Snider NT. Tumor-Selective Altered Glycosylation and Functional Attenuation of CD73 in Human Hepatocellular Carcinoma. Hepatol Commun. 2019 Aug 9;3(10):1400-1414. doi: 10.1002/hep4.1410. PMID: 31592495; PMCID: PMC6771166.

Feng W, Simpson DA, Carvajal-Garcia J, Price BA, Kumar RJ, Mose LE, Wood RD, Rashid N, Purvis JE, Parker JS, Ramsden DA, Gupta GP. Genetic determinants of cellular addiction to DNA polymerase theta. Nat Commun. 2019 Sep 19;10(1):4286. doi: 10.1038/s41467-019-12234-1. PMID: 31537809; PMCID: PMC6753077.

Antonia RJ, Castillo J, Herring LE, Serafin DS, Liu P, Graves LM, Baldwin AS, Hagan RS. TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877. Sci Rep. 2019 Sep 17;9(1):13470. doi: 10.1038/s41598-019-49707-8. PMID: 31530866; PMCID: PMC6748941.

Marvin CM, Ding S, White RE, Orlova N, Wang Q, Zywot EM, Vickerman BM, Harr L, Tarrant TK, Dayton PA, Lawrence DS. On Command Drug Delivery via Cell-Conveyed Phototherapeutics. Small. 2019 Sep;15(37):e1901442. doi: 10.1002/smll.201901442. Epub 2019 Jul 28. PMID: 31353802; PMCID: PMC6739139.

Blake DR, Vaseva AV, Hodge RG, Kline MP, Gilbert TSK, Tyagi V, Huang D, Whiten GC, Larson JE, Wang X, Pearce KH, Herring LE, Graves LM, Frye SV, Emanuele MJ, Cox AD, Der CJ. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal. 2019 Jul 16;12(590):eaav7259. doi: 10.1126/scisignal.aav7259. PMID: 31311847; PMCID: PMC6728149.

Wickenheisser VA, Zywot EM, Rabjohns EM, Lee HH, Lawrence DS, Tarrant TK. Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease. Curr Allergy Asthma Rep. 2019 Jul 2;19(8):37. doi: 10.1007/s11882-019-0869-z. PMID: 31267251; PMCID: PMC7357616.

Agajanian MJ, Walker MP, Axtman AD, Ruela-de-Sousa RR, Serafin DS, Rabinowitz AD, Graham DM, Ryan MB, Tamir T, Nakamichi Y, Gammons MV, Bennett JM, Couñago RM, Drewry DH, Elkins JM, Gileadi C, Gileadi O, Godoi PH, Kapadia N, Müller S, Santiago AS, Sorrell FJ, Wells CI, Fedorov O, Willson TM, Zuercher WJ, Major MB. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019 Jan 2;26(1):79-93.e8. doi: 10.1016/j.celrep.2018.12.023. PMID: 30605688; PMCID: PMC6315376.

Abraham DH, Anttila MM, Gallion LA, Petersen BV, Proctor A, Allbritton NL. Design of an automated capillary electrophoresis platform for single-cell analysis. Methods Enzymol. 2019;628:191-221. doi: 10.1016/bs.mie.2019.06.016. Epub 2019 Jul 18. PMID: 31668230; PMCID: PMC6933539.