Current Trainees Publication Summary

Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. Karginova O, Siegel MB, Van Swearingen AE, Deal AM, Adamo B, Sambade MJ, Bazyar S, Nikolaishvili-Feinberg N, Bash R, O’Neal S, Sandison K, Parker JS, Santos C, Darr D, Zamboni W, Lee YZ, Miller CR, Anders CK. Mol Cancer Ther. 2015 Apr;14(4):920-30. doi: 10.1158/1535-7163.MCT-14-0474. PMID: 25824335 PMCID: PMC4394032 [Available on 2016-04-01]

Breast cancer brain metastases: evidence for neuronal-like adaptation in a ‘breast-to-brain’ transition? Van Swearingen AE, Siegel MB, Anders CK. Breast Cancer Res. 2014 May 6;16(3):304. doi: 10.1186/bcr3651. PMID: 25679873 PMCID: PMC4052941

Approaches for optimal drug development and clinical trial design for breast cancer brain metastasis. Siegel MB, Van Swearingen AE, Anders CK. Oncology (Williston Park). 2014 Jul;28(7):579, 584-5. No abstract available. PMID: 25144277 Free Article

Cancer-derived mutations in KEAP1 impair NRF2 degradation but not ubiquitination. Hast BE, Cloer EW, Goldfarb D, Li H , Siesser PF, Yan F, Walter V, Zheng N, Hayes DN , Major MB. Cancer Res. 2014 Feb 1;74(3):808-17. doi: 10.1158/0008-5472.CAN-13-1655. Epub 2013 Dec 9. PMID: 24322982 PMCID: PMC3932503

Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration. Williams KA, Zhang M, Xiang S, Hu C, Wu JY, Zhang S, Ryan M, Cox AD, Der CJ, Fang B, Koomen J, Haura E, Bepler G, Nicosia SV, Matthias P, Wang C, Bai W, Zhang X. J Biol Chem. 2013 Nov 15;288(46):33156-70. doi: 10.1074/jbc.M113.472506. Epub 2013 Oct 2. PMID: 24089523 Free PMC Article PMCID: PMC3829163

GSK-3α promotes oncogenic KRAS function in pancreatic cancer via TAK1-TAB stabilization and regulation of noncanonical NF-κB. Bang D, Wilson W, Ryan M, Yeh JJ, Baldwin AS. Cancer Discov. 2013 Jun;3(6):690-703. doi: 10.1158/2159-8290.CD-12-0541. Epub 2013 Apr 1. PMID: 23547054 Free PMC Article PMCID: PMC3679268


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