2001-2004

Karnoub, AE, Worthylake, DK, Rossman, KL, Pruitt, WM, Campbell, SL, Sondek, J, and Der, CJ. (2001). Molecular basis for Rac1 recognition by guanine nucleotide exchange factors. Nat Struct Biol. 8: 1037-1041.

Decristofaro, MF, Betz, BL, Rorie, CJ, Reisman, D. N, Wang, W, and Weissman, BE. (2001). Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. J Cell Physiol. 186: 136-145.

Lyons, PD, Dunty, JM, Schaefer, EM, Schaller, MD. (2001). Inhibition of the catalytic activity of cell adhesion kinase beta by protein-tyrosine phosphatase-PEST-mediated dephosphorylation. J Biol Chem. 276:24422-24431.

Grevengoed, EE, Loureiro, JJ, Jesse, TL. and Peifer, M. (2001). Abelson kinase regulates epithelial morphogenesis in Drosophila. J Cell Biol. 155: 1185-1198.

McCartney, BM, McEwen, DG, Grevengoed, EE, Maddox, P, Bejsovec, A, and Peifer, M. (2001). Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin. Nat Cell Biol. 3: 933-938.

Decristofaro, MF, Betz, BL, Rorie, CJ, Reisman, DN, Wang, W, and Weissman, BE. (2001). Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies. J Cell Physiol. 186: 136-145.
Fiordalisi, JJ, Johnson, RL, 2nd, Ulku, AS, Der, CJ, and Cox, AD. (2001). Mammalian expression vectors for Ras family proteins: generation and use of expression constructs to analyze Ras family function. Methods Enzymol. 332: 3-36.

McFall, A, Ulku, AS, Lambert, QT, and Der, CJ. (2001). Ras inhibition of anoikis by novel effector function. Mol. Cell. Biol, 21, 5488-5499.

Strobeck, MW, Reisman, DN, Gunawardena, RW, Betz, BL, Angus, P, Knudsen, KE, Kowalik, TF, Weissman, BE. and Knudsen, ES. (2002). Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling. J Biol Chem. 277: 4782-4789.

Dunty, JM and Schaller, MD. (2002). The N termini of focal adhesion kinase family members regulate substrate phosphorylation, localization, and cell morphology. J Biol Chem. 277:45644-45654.

Grana, TM, Rusyn, EV, Zhou, H, Sartor, CI, and Cox, AD. (2002). Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase-independent signaling pathways. Cancer Res. 62: 4142-4150.

Snyder, JT, Worthylake, DK, Rossman, KL, Betts, L, Pruitt, WM, Siderovski, DP, Der, CJ, and Sondek, J. (2002). Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol. 9: 468-475.

Sunnarborg, SW, Hinkle, CL, Stevenson, M, Russell, WE, Raska, CS, Peschon, JJ, Castner, B. J, Gerhart, MJ, Paxton, RJ, Black, RA, and Lee, DC. (2002). Tumor necrosis factor-alpha converting enzyme (TACE) regulates epidermal growth factor receptor ligand availability. J Biol Chem. 277: 12838-12845.

Reisman, DN, Strobeck, MW, Betz, BL, Sciariotta, J, Funkhouser, W, Jr, Murchardt, C, Yaniv, M, Sherman, LS, Knudsen, ES, and Weissman, BE. (2002). Concomitant down-regulation of BRM and BRG1 in human tumor cell lines: differential effects on RB-mediated growth arrest vs CD44 expression. Oncogene. 21: 1196-1207.

Betz, BL, Strobeck, MW, Reisman, DN, Knudsen, ES and Weissman, BE. (2002). Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB. Oncogene. 21: 5193-5203.

Lambert, JM, Karnoub, AE, Graves, LM, Campbell, SL and Der, CJ. (2002). Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation. J Biol Chem. 277: 4770-4777.

Lambert, JM, Lambert, QT, Reuther, GW, Malliri, A, Siderovski, DP, Sondek, J, Collard, JG and Der, CJ. (2002). Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol. 4: 621-625.

Akong, K, Grevengoed, EE, Price, MH, McCartney, BM, Hayden, MA, DeNofrio, JC and Peifer, M. (2002). Drosophila APC2 and APC1 play overlapping roles in wingless signaling in the embryo and imaginal discs. Dev Biol. 250: 91-100.

Rossman, KL, Worthylake, DK, Snyder, JT, Cheng, L, Whitehead, IP and Sondek, J. (2002). Functional analysis of cdc42 residues required for guanine nucleotide exchange. J Biol Chem. 277: 50893-50898. Grevengoed, E.E. and Peifer, M. (2003). Cytoskeletal connections: building strong cells in new ways. Curr Biol. 13: R568-570.

Ning, S, Hahn, AM, Huye, LE and Pagano, JS. (2003). Interferon regulatory factor 7 regulates expression of Epstein-Barr virus latent membrane protein 1: a regulatory circuit. J Virol. 77: 9359-9368.

Lee, DC, Sunnarborg, SW, Hinkle, CL, Myers, TJ, Stevenson, MY, Russell, WE, Castner, BJ, Gerhart, MJ, Paxton, RJ, Black, RA, Chang, A and Jackson, LF. (2003). TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci. 995: 22-38.

Joyce, PL and Cox, AD. (2003). Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling. Cancer Res. 63: 7959-7967.

Lee, DC, Sunnarborg, SW, Hinkle, CL, Myers, TJ, Stevenson, MY, Russell, WE, Castner, BJ, Gerhart, MJ, Paxton, RJ, Black, RA, Chang, A and Jackson, LF. (2003). TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci. 995: 22-38.

Morrison, JA, Klingelhutz, AJ and Raab-Traub, N. (2003). Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells. J Virol. 77: 12276-12284.

Betz, BL and Weissman, BE. (2003). Hybrid capture of putative tumor suppressor genes. Methods Mol Biol. 222: 365-373.

Gabarra-Niecko, V, Schaller, MD, Dunty, JM. (2003). FAK regulates biological processes important for the pathogenesis of cancer. Cancer Metastasis Rev. 4:359-374.

Bivona, TG, Perez De Castro, I, Ahearn, IM, Grana, TM, Chiu, VK, Lockyer, PJ, Cullen, PJ, Pellicer, A, Cox, AD and Philips, MR. (2003). Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature. 424: 694-698.

Grana, TM, Sartor, CI and Cox, AD. (2003). Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the Ras oncogene enhances radiation resistance. Cancer Res. 63: 7807-7814.

Grobin, AC, Heenan, EJ, Lieberman, JA, and Morrow, AL. (2003). Perinatal neurosteriod levels influence GABAergic interneuron localization in adult rat prefrontal cortex. Journal of Neuroscience. 23: 1832-1839.

Titterington, JS, Nun, TK and Passarelli, AL. ( 2003).Functional dissection of the baculovirus late expression factor-8 gene: Sequence requirements for late gene promoter activation. Journal of General Virology. 84: 1817-1826.

Grevengoed, EE, Fox, DT, Gates, J and Peifer, M. (2003). Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled. J Cell Biol. 163: 1267-1279.

Schroeder, JA, Jackson, LF, Lee, DC. and Camenisch, TD. (2003). Form and function of developing heart valves: coordination by extracellular matrix and growth factor signaling. J Mol Med. 81: 392-403.

Ulku, AS, and Der, CJ. (2003). Ras signaling, deregulation of gene expression and oncogenesis. Cancer Treat Res. 115: 189-208.

Ulku, AS, Schafer, R, and Der, CJ. (2003). Essential role of Raf in Ras transformation and deregulation of matrix metalloproteinase expression in ovarian epithelial cells. Mol Cancer Res. 1: 1077-1088.

Vos, MD, Ellis, CA, Elam, C, Ulku, AS, Taylor, BJ, and Clark, GJ. (2003). RASSF2 is a novel K-Ras-specific effector and potential tumor suppressor. J. Biol. Chem. 278, 28045-28051.

Williams, JG, Pappu, K, and Campbell, SL. (2003). Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. Proc Natl Acad Sci U S A. 100: 6376-6381.

Cayirlioglu, P, Ward, WO, Silver Key, SC, and Duronio, RJ. (2003). Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Mol Cell Biol. 23: 2123-2134.

Collette, J, Ulku, AS, Der, CJ, Jones, A, and Erickson, AH. (2004). Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells. Int J Cancer. 112: 190-199.

Eckert, LB, Repasky, GA, Ulku, AS, McFall, A, Zhou, H, Sartor, CI, and Der, CJ. (2004). Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res. 64: 4585-4592.

Wang, L, Wakisaka, N, Tomlinson, CC, DeWire, SM, Krall, S, Pagano, JS. and Damania, B. (2004). The Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) K1 protein induces expression of angiogenic and invasion factors.Cancer Res. 64: 2774-2781.

Tomlinson, CC. and Damania, B. (2004). The K1 protein of Kaposi’s sarcoma-associated herpesvirus activates the Akt signaling pathway. J Virol. 78: 1918-1927.

Dunty, JM, Gabarra-Niecko, V, King, ML, Ceccarelli, DF, Eck, MJ and Schaller, MD. (2004). FERM domain interaction promotes FAK signaling. Mol Cell Biol. 12:5353-5368.

Ellerbroek, SM, Wennerberg, K, Arthur, WT, Dunty, JM, Bowman, DR, DeMali, KA, Der, CJ and Burridge, K. (2004). SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Mol Biol Cell. 15:3309-3319.

Hinkle, CL, Sunnarborg, SW, Loiselle, D, Parker, CE, Stevenson, M, Russell, WE and Lee, DC. (2004). Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency. J Biol Chem. 279: 24179-24188.

Sar, F, Lindsey-Boltz, LA, Subramanian, D, Croteau, DL, Hutsell, SQ, Griffith, JD and Sancar, A. (2004). Human claspin is a ring-shaped DNA-binding protein with high affinity to branched DNA structures. J Biol Chem. 279: 39289-39295.

Morrison, JA, Gulley, ML, Pathmanathan, R and Raab-Traub, N. (2004). Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Res. 64: 5251-5260.

Rorie, CJ, Thomas, VD, Chen, P, Pierce, HH, O’Bryan, JP and Weissman, BE. (2004). The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors. Cancer Res. 64: 1266-1277.

Rorie, CJ and Weissman, BE (2004). The Ews/Fli-1 fusion gene changes the status of p53 in neuroblastoma tumor cell lines. Cancer Res. 64: 7288-7295.

Solski, PA, Wilder, RS, Rossman, KL, Sondek, J, Cox, AD, Campbell, SL and Der, CJ. (2004). Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation. J. Biol. Chem. 24: 25226-25233.

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